Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/db848d79-1de7-4bc4-bde9-b07b4a767884/assets/images/large/pnas.2100225118fig05.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
![TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells - ScienceDirect TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124720303703-fx1.jpg)
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells - ScienceDirect
![Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/3122bcd6-da9c-4e9d-95cb-6447008f1862/adtp202100066-fig-0002-m.jpg)
Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease - ScienceDirect STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1931312815002930-gr1.jpg)
STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease - ScienceDirect
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124719304371-gr2.jpg)
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect
![Evolution of functional domains in STING proteins. (A) A diagram of the... | Download Scientific Diagram Evolution of functional domains in STING proteins. (A) A diagram of the... | Download Scientific Diagram](https://www.researchgate.net/publication/264633850/figure/fig5/AS:214003260366852@1428033761467/Evolution-of-functional-domains-in-STING-proteins-A-A-diagram-of-the-domain.png)
Evolution of functional domains in STING proteins. (A) A diagram of the... | Download Scientific Diagram
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124719304371-fx1.jpg)
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation - ScienceDirect
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
![Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/6ec1c239-47a4-45ff-a8ab-681aec5b23ce/adtp202100066-fig-0001-m.jpg)
Engineering the Immune Adaptor Protein STING as a Functional Carrier - Sun - 2021 - Advanced Therapeutics - Wiley Online Library
Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective | Journal of Medicinal Chemistry
![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/ccf8d4f1-6b3e-462a-9904-df0d445b1733/assets/images/large/pnas.2100225118fig04.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/a7033003-7eb9-468c-81fa-597f27b1856d/assets/images/large/pnas.2100225118fig01.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
![GRA15 promotes activation of STING. A, Diagram detailing STING domains... | Download Scientific Diagram GRA15 promotes activation of STING. A, Diagram detailing STING domains... | Download Scientific Diagram](https://www.researchgate.net/publication/335206332/figure/fig3/AS:792502516858881@1565958732688/GRA15-promotes-activation-of-STING-A-Diagram-detailing-STING-domains-CBD-and-CTT-and.jpg)
GRA15 promotes activation of STING. A, Diagram detailing STING domains... | Download Scientific Diagram
![TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS](https://www.pnas.org/cms/10.1073/pnas.2100225118/asset/c26a5f41-d400-4a08-a4b5-9f2265714777/assets/images/large/pnas.2100225118fig02.jpg)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections | PNAS
![STING activates TBK1 at the Golgi. (a) Western blots of cell lysates of... | Download Scientific Diagram STING activates TBK1 at the Golgi. (a) Western blots of cell lysates of... | Download Scientific Diagram](https://www.researchgate.net/publication/305444802/figure/fig3/AS:391143218008112@1470267218914/STING-activates-TBK1-at-the-Golgi-a-Western-blots-of-cell-lysates-of-emsCOS-1-cells.png)